Reproductive System & Sexual Disorders Strategies for Poor Responders in IVF Cycles

The desired objective of controlled ovarian stimulation (COS) is to allow the growth of a cohort of follicles and to facilitate the recovery of a large number of fertilizable oocytes. However, poor responders with low ovarian reserve often fail to respond adequately despite the maximal dose of gonadotropins administered, with the results that the number as well as quality of oocytes harvested may be very low. These results lead to a significant decrease of pregnancy rate in IVF cycles. Therefore, successful COS for poor responders continues to be a major challenge in IVF program. In this review, I will describe strategies for improvement of ovarian response to COS in poor responders. The strategies described may provide a means of augmenting follicular recruitment by endocrinological manipulation for poor responders undergoing IVF. Corresponding author: Chung-Hoon Kim, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, 86 Asanbyeongwon-gil, Songpa-gu, Seoul, Korea, Tel: 82-2-3010-3639; Fax: 82-2-476-7331; E-mail: chnkim@amc. seoul.kr Received October 17, 2011; Accepted November 16, 2011; Published November 18, 2011 Citation: Kim CH (2011) Strategies for Poor Responders in IVF Cycles. Reproductive Sys Sexual Disord S5:001. doi:10.4172/2161-038X.S5-001 Copyright: © 2011 Kim CH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.